Application of genomics to toxicology research.
Environ Health Perspect
; 110 Suppl 6: 919-23, 2002 Dec.
Article
en En
| MEDLINE
| ID: mdl-12634120
ABSTRACT
Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to risk assessment and regulatory problems. In this article, we summarize the application of gene expression information and polymorphism discovery to four areas in toxicology toxicity testing, cross-species extrapolation, understanding mechanism of action, and susceptibility.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Toxicología
/
Regulación de la Expresión Génica
/
Genómica
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Environ Health Perspect
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos