Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung.
Gene Expr Patterns
; 3(3): 279-83, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12799072
ABSTRACT
The ligand Netrin-1 and its receptors DCC and UNC5H2 are critical for the regulation of neuronal migration in nervous system development. Here we demonstrate expression of these molecules in lung development. The mRNA expression profiles of Netrin-1, DCC and UNC5H2 are developmentally regulated during embryonic mouse lung formation. Netrin-1 shows a bimodal expression pattern with elevated mRNA levels early followed by a second peak in late gestation. Peak expression of DCC occurs early in development whereas expression of UNC5H2 peaks late in development. We also demonstrate localization of Netrin-1, DCC and UNC5H2 during the stages of lung development. We present evidence that these proteins are modulated spatially in the mesenchyme and epithelium during lung organogenesis.
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Banco de datos:
MEDLINE
Asunto principal:
Moléculas de Adhesión Celular
/
Receptores de Superficie Celular
/
Proteínas Supresoras de Tumor
/
Pulmón
/
Factores de Crecimiento Nervioso
Límite:
Animals
Idioma:
En
Revista:
Gene Expr Patterns
Asunto de la revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos