Inhibition by peripheral electric stimulation of the reinstatement of morphine-induced place preference in rats and drug-craving in heroin addicts.
Beijing Da Xue Xue Bao Yi Xue Ban
; 35(3): 241-7, 2003 Jun 18.
Article
en En
| MEDLINE
| ID: mdl-12914237
ABSTRACT
OBJECTIVE:
To test the hypothesis that peripheral electric stimulation (PES) may suppress the reinstatement of morphine-induced conditioned place preference (CPP) in rats as well as the drug craving of detoxified heroin addicts in a frequency-dependent manner.METHODS:
CPP model of the rat was constructed with two compartment automatic CPP apparatus, and the craving of the heroin addicts was assessed with a visual analogue scale (VAS).RESULTS:
(1) PES of low frequency could prevent the drug priming- or foot shock-induced reinstatement of morphine CPP; (2) this effect was naloxone-reversible, suggesting a possible involvement of endogenous opioid mechanisms; and (3) PES of low frequency could also accelerate the rate of natural decay of drug craving in heroin addicts after successful abstinence.CONCLUSION:
PES might serve as a therapeutic measure for the treatment of heroin addiction.
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Banco de datos:
MEDLINE
Asunto principal:
Estimulación Eléctrica Transcutánea del Nervio
/
Condicionamiento Psicológico
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Dependencia de Heroína
/
Morfina
Límite:
Adolescent
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Adult
/
Animals
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Humans
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Male
Idioma:
En
Revista:
Beijing Da Xue Xue Bao Yi Xue Ban
Asunto de la revista:
MEDICINA
Año:
2003
Tipo del documento:
Article
País de afiliación:
China