Toremifene resistance in a rat mammary tumour model.

Kellen, J A; Georges, E; Ling, V; Dubsky, M

Kellen, J A; Georges, E; Ling, V; Dubsky, M.

Afiliación

Kellen JA; Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.

Anticancer Res ; 12(5): 1663-5, 1992.

Article en En | MEDLINE | ID: mdl-1359832

ABSTRACT

ABSTRACT

The effect of Toremifene on cell growth in vitro was tested on the R3230AC rat mammary adenocarcinoma as model. Toremifene differed from Tamoxifen in that it did not induce resistance; some cross-resistance was observed in Tamoxifen tolerant tumour cell lines. Toremifene does not influence P-glycoprotein expression in this model and at the levels studied.

Asunto(s)

Adenocarcinoma/patología; División Celular/efectos de los fármacos; Neoplasias Mamarias Experimentales/patología; Toremifeno/farmacología; Miembro 1 de la Subfamilia B de Casetes de Unión a ATP; Animales; Anticuerpos Monoclonales; Resistencia a Medicamentos; Glicoproteínas de Membrana/análisis; Ratas; Tamoxifeno/farmacología; Células Tumorales Cultivadas

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Banco de datos: MEDLINE Asunto principal: Adenocarcinoma / División Celular / Toremifeno / Neoplasias Mamarias Experimentales Límite: Animals Idioma: En Revista: Anticancer Res Año: 1992 Tipo del documento: Article País de afiliación: Canadá

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