The statistical analysis of circadian phase and amplitude in constant-routine core-temperature data.
J Biol Rhythms
; 7(3): 177-202, 1992.
Article
en En
| MEDLINE
| ID: mdl-1421473
ABSTRACT
Accurate estimation of the phases and amplitude of the endogenous circadian pacemaker from constant-routine core-temperature series is crucial for making inferences about the properties of the human biological clock from data collected under this protocol. This paper presents a set of statistical methods based on a harmonic-regression-plus-correlated-noise model for estimating the phases and the amplitude of the endogenous circadian pacemaker from constant-routine core-temperature data. The methods include a Bayesian Monte Carlo procedure for computing the uncertainty in these circadian functions. We illustrate the techniques with a detailed study of a single subject's core-temperature series and describe their relationship to other statistical methods for circadian data analysis. In our laboratory, these methods have been successfully used to analyze more than 300 constant routines and provide a highly reliable means of extracting phase and amplitude information from core-temperature data.
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Banco de datos:
MEDLINE
Asunto principal:
Temperatura Corporal
/
Ritmo Circadiano
Tipo de estudio:
Diagnostic_studies
/
Health_economic_evaluation
/
Prognostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Biol Rhythms
Asunto de la revista:
FISIOLOGIA
Año:
1992
Tipo del documento:
Article