Expansion of the mammalian 3 beta-hydroxysteroid dehydrogenase/plant dihydroflavonol reductase superfamily to include a bacterial cholesterol dehydrogenase, a bacterial UDP-galactose-4-epimerase, and open reading frames in vaccinia virus and fish lymphocystis disease virus.
FEBS Lett
; 301(1): 89-93, 1992 Apr 13.
Article
en En
| MEDLINE
| ID: mdl-1451793
ABSTRACT
Mammalian 3 beta-hydroxysteroid dehydrogenase and plant dihydroflavonol reductases are descended from a common ancestor. Here we present evidence that Nocardia cholesterol dehydrogenase, E. coli UDP-galactose-4 epimerase, and open reading frames in vaccinia virus and fish lymphocystis disease virus are homologous to 3 beta-hydroxysteroid dehydrogenase and dihydroflavonol reductase. Analysis of a multiple alignment of these sequences indicates that viral ORFs are most closely related to the mammalian 3 beta-hydroxysteroid dehydrogenases. The ancestral protein of this superfamily is likely to be one that metabolized sugar nucleotides. The sequence similarity between 3 beta-hydroxysteroid dehydrogenase and the viral ORFs is sufficient to suggest that these ORFs have an activity that is similar to 3 beta-hydroxysteroid dehydrogenase or cholesterol dehydrogenase, although the putative substrates are not yet known.
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Banco de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
UDPglucosa 4-Epimerasa
/
Proteínas Virales
/
Oxidorreductasas de Alcohol
/
Evolución Biológica
/
3-Hidroxiesteroide Deshidrogenasas
Idioma:
En
Revista:
FEBS Lett
Año:
1992
Tipo del documento:
Article