Apoptosis in male germ cells in response to cyclin A1-deficiency and cell cycle arrest.
Biochem Pharmacol
; 66(8): 1571-9, 2003 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-14555236
ABSTRACT
Male mice homozygous for a mutated allele of the cyclin A1 gene (Ccna1) are sterile due to a block in cell cycle progression before the first meiotic division. Meiosis arrest in Ccna1(-/-) spermatocytes is associated with desynapsis abnormalities, lowered MPF activity, and apoptosis as evidenced by TUNEL-positive staining. With time, adult testicular tubules exhibit severe degeneration some tubules in the older animals are almost devoid of germ cells at various stages of spermatogenesis. The mechanisms by which the cells sense the cell cycle arrest and the regulation of the decision to undergo cell death are under investigation.
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Banco de datos:
MEDLINE
Asunto principal:
Apoptosis
/
Ciclina A
/
Células Germinativas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos