Reduced capillary perfusion and permeability in human tumour xenografts treated with the VEGF signalling inhibitor ZD4190: an in vivo assessment using dynamic MR imaging and macromolecular contrast media.
Magn Reson Imaging
; 21(8): 845-51, 2003 Oct.
Article
en En
| MEDLINE
| ID: mdl-14599534
ABSTRACT
We describe the use of perfusion-permeability magnetic resonance imaging (ppMRI) to study hemodynamic parameters in human prostate tumor xenografts, following treatment with the vascular endothelial growth factor-A (VEGF) receptor tyrosine kinase inhibitor, ZD4190. Using a macromolecular contrast agent (P792), a fast MR imaging protocol and a compartmental data analysis, we were able to demonstrate a significant simultaneous reduction in tumor vascular permeability, tumor vascular volume and tumor blood flow (43%, 30% and 42%, respectively) following ZD4190 treatment (100 mg/kg orally, 24 h and 2 h prior to imaging). This study indicates that MR imaging can be used to measure multiple hemodynamic parameters in tumors, and that tumor vascular permeability, volume and flow, can change in response to acute treatment with a VEGF signaling inhibitor.
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Banco de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
Triazoles
/
Angiografía por Resonancia Magnética
/
Medios de Contraste
/
Inhibidores de la Angiogénesis
/
Factor A de Crecimiento Endotelial Vascular
/
Neoplasias Experimentales
/
Antineoplásicos
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
En
Revista:
Magn Reson Imaging
Año:
2003
Tipo del documento:
Article
País de afiliación:
Francia