Measurement of skeletal muscle mass in Duchenne muscular dystrophy: use of 24-h creatinine excretion.
Acta Diabetol
; 40 Suppl 1: S290-2, 2003 Oct.
Article
en En
| MEDLINE
| ID: mdl-14618496
ABSTRACT
Creatinine concentration in 24-h urine has been proposed as an indirect measure of body skeletal muscle mass (SMM). We attempted to correlate urinary creatinine levels with SMM in eight patients with Duchenne muscular dystrophy, a progressive disease in which the degree of muscle wasting parallels the rate of progression. Magnetic resonance imaging and a newly developed protocol for image analysis were used for the measurement of SMM. The patients ate a creatine-free diet for the week before urine collection. Creatinine was measured with an enzymatic-colorimetric method. Mean (+/-SD) SMM value was 5.4+/-2.5 kg and urine creatinine levels 205.8+/-96.4 mg/day. Daily urinary creatinine excretion did not correlate with SMM. The simple creatinine determination in urine cannot predict SMM in Duchenne muscular dystrophy.
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Banco de datos:
MEDLINE
Asunto principal:
Músculo Esquelético
/
Distrofia Muscular de Duchenne
/
Creatinina
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Acta Diabetol
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Italia