Weight reduction with very-low-caloric diet and endothelial function in overweight adults: role of plasma glucose.
Arterioscler Thromb Vasc Biol
; 24(1): 124-8, 2004 Jan.
Article
en En
| MEDLINE
| ID: mdl-14656740
ABSTRACT
OBJECTIVE:
Obesity is associated with endothelial dysfunction that may contribute to the development of atherosclerosis. We studied whether weight reduction improves endothelial function in overweight individuals. METHODS ANDRESULTS:
Flow-mediated endothelium-dependent vasodilation of the brachial artery was measured in 67 adults (age 46+/-7 years, body mass index 35.2+/-5.4 kg/m2) before and after a 6-week weight reduction program induced by very-low-calorie diet (daily energy 580 kcal/2.3 MJ). Caloric restriction reduced body weight from 101+/-18 to 90+/-17 kg. Flow-mediated vasodilation increased from 5.5%+/-3.7 to 8.8%+/-3.7% (P<0.0001). Nitrate-mediated vasodilation was not significantly affected. The improvement in flow-mediated dilation was associated with the reduction in plasma glucose concentration (P=0.0003). This relationship was independent of changes in weight, serum lipids, oxidized LDL, C-reactive protein, adiponectin, blood pressure, and insulin.CONCLUSIONS:
Weight reduction with very-low-calorie diet improves flow-mediated vasodilation in obese individuals. This improvement is related to the reduction in plasma glucose concentration. These observations suggest that changes in glucose metabolism may determine endothelial vasodilatory function in obesity.
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Banco de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Pérdida de Peso
/
Péptidos y Proteínas de Señalización Intercelular
/
Dieta Reductora
/
Obesidad
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arterioscler Thromb Vasc Biol
Asunto de la revista:
ANGIOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Finlandia