Preoperative leuprolide acetate combined with Interceed* optimally reduces uterine adhesions and fibrosis in a rabbit model.
Fertil Steril
; 81(1): 194-7, 2004 Jan.
Article
en En
| MEDLINE
| ID: mdl-14711566
ABSTRACT
OBJECTIVE:
To determine the optimal approach to prevent adhesions comparing leuprolide acetate (GnRH-a), Interceed (oxidized regenerated cellulose; Johnson & Johnson Medical, Inc., New Brunswick, NJ), and a combination of leuprolide with Interceed in a rabbit uterine horn adhesion model.DESIGN:
Prospective, randomized, blinded study.SETTING:
Certified animal care facility. ANIMAL(S) Twenty-eight sexually mature, female New Zealand White rabbits. INTERVENTION(S) Animals were prospectively randomized (by number generator) to receive GnRH-a or saline. After 6 weeks, standard surgical manipulations were performed at three sites in each uterine horn by [1]. suture, [2]. unipolar cautery, and [3]. superficial abrasion. Interceed was applied over one randomly assigned uterine horn only. Six weeks after surgery, uterine adhesions were assessed visually, and tissue fibrosis was assessed by histology. MAIN OUTCOME MEASURE(S) Presence or absence of adhesions and microscopic tissue fibrosis. RESULT(S) Gonadotropin-releasing hormone agonist significantly decreased adhesions, whereas Interceed alone did not reduce adhesions. However, GnRH agonist plus Interceed was the most effective measure to reduce tissue fibrosis. CONCLUSION(S) Preoperative GnRH-a is more effective than Interceed in preventing surgical adhesions in the rabbit uterine horn. However, preoperative GnRH-a plus Interceed may provide optimal results in this animal model, because microscopic tissue fibrosis is minimized with this combination.
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Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Útero
/
Celulosa Oxidada
/
Leuprolida
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Fertil Steril
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos