Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice.
Nat Immunol
; 5(2): 224-9, 2004 Feb.
Article
en En
| MEDLINE
| ID: mdl-14716311
ABSTRACT
The generation of protective antibodies requires somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin genes. Here we show that mice mutant for exonuclease 1 (Exo1), which participates in DNA mismatch repair (MMR), have decreased CSR and changes in the characteristics of SHM similar to those previously observed in mice mutant for the MMR protein Msh2. Exo1 is thus the first exonuclease shown to be involved in SHM and CSR. The phenotype of Exo1(-/-) mice and the finding that Exo1 and Mlh1 are physically associated with mutating variable regions support the idea that Exo1 and MMR participate directly in SHM and CSR.
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Banco de datos:
MEDLINE
Asunto principal:
Cambio de Clase de Inmunoglobulina
/
Hipermutación Somática de Inmunoglobulina
/
Exodesoxirribonucleasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos