The protein kinase PKR: a molecular clock that sequentially activates survival and death programs.
EMBO J
; 23(3): 564-71, 2004 Feb 11.
Article
en En
| MEDLINE
| ID: mdl-14749731
ABSTRACT
Cell death and survival play a key role in the immune system as well as during development. The control mechanisms that balance cell survival against cell death are not well understood. Here we report a novel strategy used by a single protein to regulate chronologically cell survival and death. The interferon-induced protein kinase PKR acts as a molecular clock by using catalysis-dependent and -independent activities to temporally induce cell survival prior to cell death. We show that the proapoptotic protein PKR surprisingly activates a survival pathway, which is mediated by NF-kappaB to delay apoptosis. Cell death is then induced by PKR through the phosphorylation of eIF-2alpha. This unique temporal control might serve as a paradigm for other kinases whose catalytic activity is not required for all of their functions.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Apoptosis
/
EIF-2 Quinasa
Límite:
Animals
Idioma:
En
Revista:
EMBO J
Año:
2004
Tipo del documento:
Article
País de afiliación:
Suiza