Reliability of quantal parameter estimates and their changes during long-term potentiation in guinea pig hippocampal slices.
Neurosci Lett
; 146(1): 111-4, 1992 Oct 26.
Article
en En
| MEDLINE
| ID: mdl-1475043
ABSTRACT
Previously we found increases in quantal content (m) and smaller increases in quantal size (v) during long-term potentiation (LTP) in CA1 of hippocampal slices. However, the validity of the deconvolution technique was questioned recently because v estimates correlated with the noise standard deviation (Sn). In computer simulations we show a double-step dependence of v on Sn/v correct v estimates (within +/- 20%) for Sn/v < or = 0.5 and overestimates (correlated with Sn) for Sn/v > 0.5. A novel 'noise addition' procedure is proposed for accepting reliable solutions on the basis of the double-step relationship between v and Sn. Quantal analysis of LTP for more reliable solutions confirmed previous conclusions.
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Banco de datos:
MEDLINE
Asunto principal:
Hipocampo
/
Plasticidad Neuronal
Tipo de estudio:
Health_economic_evaluation
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1992
Tipo del documento:
Article