Expression of HBsAg and HBcAg in liver tissue: correlation with disease activity.
Histol Histopathol
; 7(3): 493-9, 1992 Jul.
Article
en En
| MEDLINE
| ID: mdl-1504471
ABSTRACT
The patterns of Hepatitis B surface antigen (HBsAg) and Hepatitis B core antigen (HBcAg) expression were studied in liver biopsies taken from 41 patients with chronic HBV disease. Immunohistochemical methods were used on deparaffinized sections for the identification of HBsAg and HBcAg in liver tissue. Twenty-one of the 41 cases (51.2%) were classified as inactive liver disease and 20 (48.8%) as active liver disease. In liver biopsies with inactive disease, HBsAg demonstrated varying types of cytoplasmic expression in a rather high number of hepatocytes distributed mainly in clusters, while HBcAg was rarely expressed in liver nuclei. On the other hand, in liver biopsies with active disease HBsAg was characterized by a diffuse cytoplasmic expression in a few discrete hepatocytes, while HBcAg was expressed in the nuclei of the hepatocytes in 70% of the cases and in half of the positive cases it was also detected in the cytoplasm. In conclusion, HBsAg expression in a few scattered hepatocytes correlates with active liver disease and positive HBcAg, while varying HBsAg cytoplasmic expression in a rather high number of clustered hepatocytes is related to chronic inactive liver disease and negative expression of HBcAg.
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Banco de datos:
MEDLINE
Asunto principal:
Hepatitis B
/
Antígenos del Núcleo de la Hepatitis B
/
Antígenos de Superficie de la Hepatitis B
/
Hepatitis Crónica
Límite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Histol Histopathol
Asunto de la revista:
HISTOLOGIA
/
PATOLOGIA
Año:
1992
Tipo del documento:
Article
País de afiliación:
Grecia