Efficiency, fidelity and enzymatic switching during translesion DNA synthesis.
Cell Cycle
; 3(5): 580-3, 2004 May.
Article
en En
| MEDLINE
| ID: mdl-15118407
ABSTRACT
More than half of the 16 human DNA polymerases may have some role in DNA replication and potentially modulate the biological effects of DNA template lesions that impede replication fork progression. As one approach to understand how multiple polymerases are coordinated at the fork, we recently quantified the efficiency and fidelity with which one particular translesion synthesis enzyme, human DNA polymerase eta, copies templates containing cis-syn thymine dimers. Several observations from that study were unanticipated. Here we discuss the structural and biological implications of those results in light of earlier studies of translesion synthesis.
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Banco de datos:
MEDLINE
Asunto principal:
ADN Polimerasa Dirigida por ADN
/
Replicación del ADN
Límite:
Humans
Idioma:
En
Revista:
Cell Cycle
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos