Use of a hemoglobin-based oxygen carrier in the treatment of severe anemia.
Obstet Gynecol
; 103(5 Pt 2): 1096-9, 2004 May.
Article
en En
| MEDLINE
| ID: mdl-15121621
BACKGROUND: Hemoglobin-based oxygen carriers hold promise for the treatment of acute anemia. CASE: We report a patient with severe dysfunctional uterine bleeding. During her hospitalization, her lowest hemoglobin level was 3.1 g/dL, with a hematocrit of 9.3%. An investigational product, o-raffinose cross-linked human hemoglobin solution (hemoglobin raffimer), was infused along with ongoing high-dose recombinant human erythropoietin and estrogen. The time until the patient's own hematopoiesis provided sufficient red blood cell mass was successfully managed by reducing oxygen demand and providing multiple hemoglobin-based oxygen carrier infusions. After hemoglobin-based oxygen carrier administration, transient pulmonary hypertension and fever were noted. She was discharged after corrective surgery 7 days after hemoglobin-based oxygen carrier administration with a hemoglobin level of 7.8 g/dL. CONCLUSION: The hemoglobin level-based oxygen carrier improved oxygen delivery and permitted uterine corrective surgery.
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Banco de datos:
MEDLINE
Asunto principal:
Rafinosa
/
Hemoglobinas
/
Anemia
/
Menorragia
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Obstet Gynecol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos