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Use of a hemoglobin-based oxygen carrier in the treatment of severe anemia.
Shander, Aryeh; Alalawi, Raed; Seeber, Petra; Lui, John.
Afiliación
  • Shander A; Department of Anesthesiology and Critical Care Medicine, Englewood Hospital and Medical Center, Englewood, New Jersey 07631, USA. aryeh.shander@ehmc.com
Obstet Gynecol ; 103(5 Pt 2): 1096-9, 2004 May.
Article en En | MEDLINE | ID: mdl-15121621
BACKGROUND: Hemoglobin-based oxygen carriers hold promise for the treatment of acute anemia. CASE: We report a patient with severe dysfunctional uterine bleeding. During her hospitalization, her lowest hemoglobin level was 3.1 g/dL, with a hematocrit of 9.3%. An investigational product, o-raffinose cross-linked human hemoglobin solution (hemoglobin raffimer), was infused along with ongoing high-dose recombinant human erythropoietin and estrogen. The time until the patient's own hematopoiesis provided sufficient red blood cell mass was successfully managed by reducing oxygen demand and providing multiple hemoglobin-based oxygen carrier infusions. After hemoglobin-based oxygen carrier administration, transient pulmonary hypertension and fever were noted. She was discharged after corrective surgery 7 days after hemoglobin-based oxygen carrier administration with a hemoglobin level of 7.8 g/dL. CONCLUSION: The hemoglobin level-based oxygen carrier improved oxygen delivery and permitted uterine corrective surgery.
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Banco de datos: MEDLINE Asunto principal: Rafinosa / Hemoglobinas / Anemia / Menorragia Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans Idioma: En Revista: Obstet Gynecol Año: 2004 Tipo del documento: Article País de afiliación: Estados Unidos
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Banco de datos: MEDLINE Asunto principal: Rafinosa / Hemoglobinas / Anemia / Menorragia Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans Idioma: En Revista: Obstet Gynecol Año: 2004 Tipo del documento: Article País de afiliación: Estados Unidos