[Effect of overall alkali of Tongbiling on CD69 expression activated mouse T lymphocytes].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 19(1): 93-4, 2003 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-15132920
ABSTRACT
AIM:
To investigate the effect of overall alkali of Tongbiling(TBL) on CD69 expression on activated mouse T lymphocytes and its possible mechanism.METHODS:
Phorbol 12,13-dibutyrate(PDB) or concanavalin (ConA) were added successively into mouse lymphocytic culture with various concentration of overall alkali TBL. After 24 hours, CD69 expression rate on mouse T lymphocytes activated with PDB or ConA was analyzed by flow cytometry.RESULTS:
Overall alkali TBL could significantly down-regulate CD69 expression in a dose-dependent manner.CONCLUSION:
Overall alkali TBL can significantly inhibit CD69 expression on activated mouse T lymphocytes. This study provided an experimental basis for application of overall alkali TBL to treatment of rheumatoid arthritis.
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Banco de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Medicamentos Herbarios Chinos
/
Linfocitos T
/
Antígenos de Diferenciación de Linfocitos T
/
Antígenos CD
/
Alcaloides
Límite:
Animals
Idioma:
Zh
Revista:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
China