Staphylococcus aureus peptidoglycan stimulates granulocyte macrophage colony-stimulating factor production from human epidermal keratinocytes via mitogen-activated protein kinases.
FEBS Lett
; 566(1-3): 195-200, 2004 May 21.
Article
en En
| MEDLINE
| ID: mdl-15147894
ABSTRACT
Epidermal keratinocytes with atopic dermatitis (AD) overproduce mediators such as granulocyte macrophage colony-stimulating factor (GM-CSF), which are associated with pathology of AD. We found that peptidoglycan (PGN) of Staphylococcus aureus, which is frequently observed in lesion with AD, induced the production of numerous mediators such as GM-CSF and regulated on activation, normal T-cell expressed and secreted. Moreover, PGN phosphorylated extracellular-signal-regulated kinases and p38 mitogen-activated protein kinase, which were involved in the induction of GM-CSF expression. These results suggested that PGN of S. aureus directly exacerbates inflammation of inflammatory skin disease.
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Banco de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
/
Peptidoglicano
/
Queratinocitos
/
Factor Estimulante de Colonias de Granulocitos y Macrófagos
/
Proteínas Quinasas Activadas por Mitógenos
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón