[Comparison of pelvic transarterial chemoembolization with lipiodol ultra-fluid carboplatin and transarterial carboplatin through experiment in dogs].

ABSTRACT

BACKGROUND & OBJECTIVE: Transarterial chemoembolization, based on transarterial chemotherapy, is a new treatment for malignant neoplasms. This study was to investigate distribution of platinum (Pt) in blood and uterine tissue after infusing different carboplatin arterially. METHODS: Fourteen female dogs were randomly divided into 2 groups embolizational group (group A, 7 dogs),and chemotherapy group (group B, 7 dogs). In group A, carboplatin (12 mg/kg), mingled with lipidol ultra-fluid (0.2 ml/kg), was injected into dogs' iliac arteries. In group B, carboplatin (12 mg/kg), dissolved in 5% glucose, was injected into the same arteries. The uterine tissues and blood samples were collected at different time points, concentrations of Pt in samples were measured by atomic absorption method. RESULTS: Peak concentration of Pt in uterine tissues of group A was (215.0+/-17.6) microg/g, that of group B was (211.3+/-40.1) microg/g (P >0.05), the peak appeared at 0 min in both groups. Area under concentration-time curve (AUC) of Pt in tissues of group A was (13.9+/-3.9) mg x min x g(-1), significantly larger than that of group B (5.9+/-0.6) mg x min x g(-1). Peak concentration of Pt in plasma of group A was (8.7+/-12.5) microg/g, that of group B was (16.7+/-3.6) microg/g. AUC(0-240 min) was (0.5+/-0.1) mg x min x g(-1) in group A,and (1.2+/-0.4) mg x min x g(-1) in group B (P< 0.05). CONCLUSION: Compared with arterial chemotherapy, arterial chemo- embolization may result in higher Pt concentration in local area, and lower Pt concentration in plasma, it may reduce the systemic toxicities, and enhance local effect on tumor.