The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors.
Bioorg Med Chem
; 13(1): 59-68, 2005 Jan 03.
Article
en En
| MEDLINE
| ID: mdl-15582452
ABSTRACT
Recently, trans-disubstituted oxo-aryl-piperidines have been identified as small molecule nonpeptide renin inhibitors for the modulation of hypertension. Herein, we report on the discovery and preparation of a new class of novel cis-disubstituted amino-aryl-piperidines as a mixture of enantiomers that are potent in vitro renin inhibitors and also, possess in vivo antihypertensive activity in a double transgenic mouse model.
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Banco de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Renina
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos