Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Nat Med
; 11(1): 32-4, 2005 Jan.
Article
en En
| MEDLINE
| ID: mdl-15619627
ABSTRACT
The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.
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Banco de datos:
MEDLINE
Asunto principal:
Timo
/
Trasplante Heterólogo
/
Trasplante de Riñón
/
Galactosiltransferasas
Límite:
Animals
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos