Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.
Nat Med
; 11(1): 29-31, 2005 Jan.
Article
en En
| MEDLINE
| ID: mdl-15619628
ABSTRACT
Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-alpha1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies.
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Banco de datos:
MEDLINE
Asunto principal:
Trasplante Heterólogo
/
Trasplante de Corazón
/
Disacáridos
/
Galactosiltransferasas
Límite:
Animals
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos