Intersegmental recombination between the haemagglutinin and matrix genes was responsible for the emergence of a highly pathogenic H7N3 avian influenza virus in British Columbia.
J Gen Virol
; 86(Pt 3): 727-731, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15722533
ABSTRACT
In February 2004 a highly pathogenic avian influenza (HPAI) outbreak erupted in British Columbia. Investigations indicated that the responsible HPAI H7N3 virus emerged suddenly from a low pathogenic precursor. Analysis of the haemagglutinin (HA) genes of the low and high pathogenic viruses isolated from the index farm revealed the only difference to be a 21 nt insert at the HA cleavage site of the highly pathogenic avian influenza virus. It was deduced that this insert most probably arose as a result of non-homologous recombination between the HA and matrix genes of the same virus. Over the course of the outbreak, a total of 37 isolates with, and 3 isolates without inserts were characterized. The events described here appear very similar to those which occurred in Chile in 2002 where the virulence shift of another H7N3 virus was attributed to non-homologous recombination between the HA and nucleoprotein genes.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
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Recombinación Genética
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Proteínas de la Matriz Viral
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Brotes de Enfermedades
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Gripe Aviar
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Hemaglutininas Virales
Límite:
Animals
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Gen Virol
Año:
2005
Tipo del documento:
Article