Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.

Yong, Hong; Gu, Yu Gui; Clark, Richard F; Marron, Thomas; Ma, Zhenkun; Soni, Niru; Stone, Gregory G; Nilius, Angela M; Marsh, Kennan; Djuric, Stevan W

Yong, Hong; Gu, Yu Gui; Clark, Richard F; Marron, Thomas; Ma, Zhenkun; Soni, Niru; Stone, Gregory G; Nilius, Angela M; Marsh, Kennan; Djuric, Stevan W.

Afiliación

Yong H; Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA. hong.yong@abbott.com

Bioorg Med Chem Lett ; 15(10): 2653-8, 2005 May 16.

Article en En | MEDLINE | ID: mdl-15863336

ABSTRACT

ABSTRACT

A novel series of 6-O-arylpropargyl diazalides was synthesized and evaluated for their antibacterial activity. Members of this series exhibited potent activity against erythromycin-resistant respiratory tract pathogens.

Asunto(s)

Antibacterianos/síntesis química; Antibacterianos/farmacología; Farmacorresistencia Microbiana; Resistencia a Múltiples Medicamentos; Propanoles/síntesis química; Propanoles/farmacología; Streptococcus pneumoniae/efectos de los fármacos; Tilosina/análogos & derivados; Tilosina/síntesis química; Tilosina/farmacología; Antibacterianos/química; Antibacterianos/farmacocinética; Disponibilidad Biológica; Semivida; Pruebas de Sensibilidad Microbiana; Propanoles/química; Relación Estructura-Actividad; Tilosina/química

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Banco de datos: MEDLINE Asunto principal: Streptococcus pneumoniae / Farmacorresistencia Microbiana / Tilosina / Resistencia a Múltiples Medicamentos / Propanoles / Antibacterianos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2005 Tipo del documento: Article País de afiliación: Estados Unidos

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