Purine salvage as a metabolite and energy saving mechanism in the ocular lens.
Curr Eye Res
; 11(5): 435-44, 1992 May.
Article
en En
| MEDLINE
| ID: mdl-1606839
ABSTRACT
The ocular lens is an organ which depends mainly on anaerobic processes to obtain the metabolic energy required for the maintenance of its physiological functions. In these circumstances, the purine salvage pathway enzymes, by using preformed purine rings, and allowing the utilization of the activated ribose moiety of nucleosides, might be of relevance as an energy saving device. In this paper we show that the calf lens possesses many enzymes of the purine salvage pathway, with a particularly high specific activity of purine nucleoside phosphorylase (EC 2.4.2.1), and that the isolated lens epithelium can actively convert adenine and adenosine into adenine nucleotides. In addition, as in bacteria and red blood cells, inosine and adenosine in the lens, acting as ribose donors, exert a profound effect on the process of adenine conversion into ATP.
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Banco de datos:
MEDLINE
Asunto principal:
Adenosina Trifosfato
/
Cápsula del Cristalino
Límite:
Animals
Idioma:
En
Revista:
Curr Eye Res
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia