[A comparison of clinical and virological characteristics of 1686 cases of HBeAg-negative and HBeAg-positive chronic hepatitis B].
Zhonghua Nei Ke Za Zhi
; 44(9): 648-51, 2005 Sep.
Article
en Zh
| MEDLINE
| ID: mdl-16202251
ABSTRACT
OBJECTIVE:
To investigate the clinical characteristics of HBeAg-negative and HBeAg-positive chronic hepatitis B (CHB).METHODS:
A total of 1686 hospitalized CHB cases were analyzed retrospectively. The serum ALT values, HBV DNA levels and hepatic inflammation and fibrosis were analyzed by their serum HBeAg status.RESULTS:
Among the 1686 cases, 628 (37.3%) were HBeAg-negative and 1058 (62.7%) were HBeAg-positive. Compared with HBeAg-positive group, HBeAg-negative group had a lower serum ALT and HBV DNA levels. However, hepatic necroinflammation grading and fibrosis staging in HBeAg-negative group were more advanced than that of HBeAg-positive group. Irrespective to serum HBeAg status, patients with serum HBV DNA less than 10(5)copies/ml, had a lower hepatic necroinflammation activity.CONCLUSIONS:
HBeAg-positive CHB is still the predominant form of CHB in Chinese patients. Compared with patients with low HBV replication, patients with active HBV replication had a higher hepatic necroinflammation activity. The liver histological grading and staging in HBeAg-negative CHB patients were more advanced than that in HBeAg-positive patients.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Hepatitis B Crónica
/
Antígenos e de la Hepatitis B
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Zh
Revista:
Zhonghua Nei Ke Za Zhi
Año:
2005
Tipo del documento:
Article
País de afiliación:
China