Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients.
J Pharmacokinet Pharmacodyn
; 32(3-4): 521-45, 2005 Aug.
Article
en En
| MEDLINE
| ID: mdl-16307208
ABSTRACT
Optimal sampling times are found for a study in which one of the primary purposes is to develop a model of the pharmacokinetics of itraconazole in patients with cystic fibrosis for both capsule and solution doses. The optimal design is expected to produce reliable estimates of population parameters for two different structural PK models. Data collected at these sampling times are also expected to provide the researchers with sufficient information to reasonably discriminate between the two competing structural models.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Itraconazol
/
Fibrosis Quística
/
Modelos Biológicos
/
Antifúngicos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Pharmacokinet Pharmacodyn
Asunto de la revista:
FARMACOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Australia