Predictors of major hemorrhage following fibrinolysis for acute pulmonary embolism.
Am J Cardiol
; 97(1): 127-9, 2006 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-16377297
ABSTRACT
One hundred four patients at Brigham and Women's Hospital who received alteplase for acute pulmonary embolism were evaluated. Major bleeding occurred in 20 patients (19.2%). The principal site of bleeding was unknown in 9 (45.0%), gastrointestinal in 6 (30.0%), retroperitoneal in 3 (15.0%), intracranial in 1 (5.0%), and splenic in 1 (5.0%). Independent predictors of major hemorrhage were the administration of catecholamines for systemic arterial hypotension (odds ratio [OR] 115, 95% confidence interval [CI] 9.4 to 1,410.9, p < 0.001), cancer (OR 16.0, 95% CI 3.2 to 80, p = 0.004), diabetes mellitus (OR 9.6, 95% CI 1.7 to 54, p = 0.010), and elevated international normalized ratio before fibrinolysis (OR 5.8, 95% CI 1.5 to 22, p = 0.012).
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Banco de datos:
MEDLINE
Asunto principal:
Embolia Pulmonar
/
Activador de Tejido Plasminógeno
/
Fibrinolíticos
/
Hemorragia
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Cardiol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos