Convergent, stereoselective synthesis of the GHIJ fragment of brevetoxin A.
Org Lett
; 8(1): 159-62, 2006 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-16381592
ABSTRACT
[reaction see text] A stereoselective synthesis of the GHIJ fragment of brevetoxin A utilizing a convergent assembly strategy is described. Glycolate alkylation, ring-closing metathesis, and Hosomi-Sakurai reactions were central operations in the construction of the G ring and J ring subunits, which were united through a Horner-Wadsworth-Emmons coupling. Subsequent dehydrative cyclization produced an endocyclic enol ether that was further elaborated to the tetracyclic GHIJ fragment of brevetoxin A.
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Banco de datos:
MEDLINE
Asunto principal:
Oxocinas
/
Toxinas Marinas
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos