Ocular effects of topical 0.03% bimatoprost solution in normotensive feline eyes.
Vet Ophthalmol
; 9(1): 39-43, 2006.
Article
en En
| MEDLINE
| ID: mdl-16409244
ABSTRACT
OBJECTIVE:
The current study was undertaken to evaluate the effects of topically applied bimatoprost, an ocular hypotensive lipid, on intraocular pressure (IOP) and pupil size (PS) in healthy cats. ANIMAL STUDIED Nine European Shorthair cats free from clinically relevant ocular abnormalities were used in the study. PROCEDURES Pretreatment baseline measurements of IOP and PS were obtained bilaterally at 8 am, 2 pm, and 8 pm for five consecutive days (days 1 to 5). Then the cats received one drop twice daily (10 am and 6 pm) of bimatoprost ophthalmic solution 0.03% (Lumigantrade mark, Allergan Inc., Irvine, CA USA), in one randomly selected eye and one drop of artificial tears in the fellow eye (control eye) for 5 days (days 6 to 10). Values for IOP and PS were obtained under the same conditions as in the pretreatment phase. The potential for ocular irritation following bimatoprost application was also evaluated.RESULTS:
During the pretreatment period, the mean IOP and mean PS were not significantly different between the eyes subsequently treated with bimatoprost and those subsequently determined as controls. During the treatment period, the mean IOP in bimatoprost-treated eyes was not significantly lower than in control eyes (14.2+/-2.3 vs. 14.5+/-2.8 mmHg). Mean IOP in control eyes was not significantly changed at any time during the study period. A marked reduction of PS was seen in all bimatoprost-treated eyes, but no other clinically relevant side effects were observed.CONCLUSION:
Twice daily topical applications of bimatoprost produced miosis but had no significant effect on IOP in healthy cats.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedades de los Gatos
/
Miosis
/
Pupila
/
Presión Intraocular
/
Lípidos
Límite:
Animals
Idioma:
En
Revista:
Vet Ophthalmol
Asunto de la revista:
MEDICINA VETERINARIA
/
OFTALMOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Francia