[Successful salvage therapy of continuous low-dose irinotecan for a patient with relapsed and refractory diffuse large B-cell lymphoma].
Rinsho Ketsueki
; 46(9): 1074-7, 2005 Sep.
Article
en Ja
| MEDLINE
| ID: mdl-16440768
ABSTRACT
A 46-year-old man with relapsed and refractory diffuse large B-cell lymphoma after salvage therapy (EPOCH and ESHAP regimens) was treated with continuous low-dose CPT-11 (irinotecan hydrochloride) at 30 mg/day (20 mg/m2/day) for three consecutive days every week. The patient's general condition and both LDH and CRP, tumor related markers, improved dramatically. Complete remission was achieved after a 10-week cycle of therapy without severe adverse effects. Unfortunately, the lymphoma relapsed after allogeneic hematopoietic stem cell transplantation, low-dose CPT-11 therapy was used again to palliate tumor symptoms for 12 months. This therapy may be a useful salvage and palliative chemotherapy for relapsed and refractory lymphoma.
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Banco de datos:
MEDLINE
Asunto principal:
Camptotecina
/
Linfoma de Células B
/
Linfoma de Células B Grandes Difuso
/
Terapia Recuperativa
/
Antineoplásicos Fitogénicos
Límite:
Humans
/
Male
/
Middle aged
Idioma:
Ja
Revista:
Rinsho Ketsueki
Año:
2005
Tipo del documento:
Article