[Effects of enhanced external counterpulsation in atherosclerosis and NF-kappaB expression: a pig model with hypercholesterolemia].
Zhonghua Bing Li Xue Za Zhi
; 35(3): 159-64, 2006 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-16630505
ABSTRACT
OBJECTIVE:
To study the effects of enhanced external counterpulsation (EECP) on the vascular morphology, and endothelial function using experimentally induced hypercholesterolemic pigs.METHODS:
Thirty five male pigs were randomly divided into three groups 7 normal control animals, 11 hypercholesterolemic animals, and 17 hypercholesterolemic animals receiving EECP. Serum cholesterol was measured. The coronary arteries and aortas were sampled for histopathologic and ultrastructural examination. The NF-kappaB protein expression of porcine coronary arteries was investigated by immunofluorescence.RESULTS:
Compared with the normal controls, serum cholesterol levels were significantly higher in the hypercholesterolemic animals with or without EECP. The plaque/intimal area ratio of the aorta decreased significantly in animals receiving EECP [(3.33 +/- 2.40)%, versus (12.03 +/- 7.12)% in those without EECP, P < 0.05]. Lipid deposition, endothelial damage and proliferation of smooth muscle cells were less severe in animals receiving EECP than those not. Moreover, activation and expression of NF-kappaB also decreased significantly (P < 0.05) in animals receiving EECP.CONCLUSIONS:
EECP improves the morphology and function of vascular endothelium, and retards the development and progression of atherosclerosis, likely through the inhibition of NF-kappaB signaling pathway.
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Banco de datos:
MEDLINE
Asunto principal:
Contrapulsación
/
FN-kappa B
/
Aterosclerosis
/
Hipercolesterolemia
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Zhonghua Bing Li Xue Za Zhi
Año:
2006
Tipo del documento:
Article
País de afiliación:
China