Haemophilus influenzae type b reemergence after combination immunization.
Emerg Infect Dis
; 12(6): 937-41, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16707049
ABSTRACT
An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl-ribitol phosphate antibody concentration and avidity before and after a Hib booster in 176 children 2-4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertussis-Hib or DTaP-Hib) combination vaccine in infancy. We also measured pharyngeal carriage of Hib. Antibody concentrations before and avidity indices after vaccination were low (geometric mean concentration 0.46 mug/mL, 95% confidence interval [CI] 0.36-0.58; geometric mean avidity index 0.16, 95% CI 0.14-0.18) and inversely related to the number of previous doses of DTaP-Hib (p = 0.02 and p<0.001, respectively). Hib was found in 2.1% (95% CI 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polisacáridos Bacterianos
/
Vacunas contra Haemophilus
/
Haemophilus influenzae tipo b
/
Vacunas contra Difteria, Tétanos y Tos Ferina Acelular
/
Infecciones por Haemophilus
Límite:
Child, preschool
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Emerg Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2006
Tipo del documento:
Article
País de afiliación:
Reino Unido