The iron/lead transporter superfamily of Fe/Pb2+ uptake systems.
J Mol Microbiol Biotechnol
; 11(1-2): 1-9, 2006.
Article
en En
| MEDLINE
| ID: mdl-16825785
ABSTRACT
Oxidase-dependent ferrous iron uptake transporters of the OFeT family and lead uptake transporters of the PbrT family comprise the iron/lead transporter (ILT) superfamily (transporter classification No. 9.A.10). All sequenced homologues of the ILT superfamily were multiply aligned, and conserved motifs, including fully conserved acidic residues in putative transmembrane segments (TMSs) 1 and 4, previously implicated in heavy metal binding, were identified. Topological analyses confirmed the presence of 7 conserved TMSs in a 3 + 3 + 1 arrangement where the two 3 TMS elements are internally repeated. Phylogenetic analyses revealed the presence of several sequence divergent clusters of orthologous proteins that group roughly according to the phylogenes of the organisms of origin. The results serve to characterize and provide evolutionary insight into a novel superfamily of heavy metal uptake transporters.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Proteínas Fúngicas
/
Proteínas Arqueales
/
Proteínas de Transporte de Catión
/
Hierro
/
Plomo
Idioma:
En
Revista:
J Mol Microbiol Biotechnol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOTECNOLOGIA
/
MICROBIOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos