Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants.
Int J Pharm
; 323(1-2): 153-60, 2006 Oct 12.
Article
en En
| MEDLINE
| ID: mdl-16828244
Amorphous nanoparticles of cefuroxime axetil (CFA), a poorly water-soluble drug, were produced by the controlled nanoprecipitation method without any surfactants at room temperature. The influence of the operation parameters, such as the types of solvent and anti-solvent, the stirring speed, the solvent/anti-solvent (S/AS) volume ratio, the drug concentration and the precipitation temperature, were experimentally investigated. The results indicated that increasing the stirring speed and the S/AS volume, decreasing the drug concentration and the temperature favored to decrease the particle size from 700 to 900 nm to approximately 300 nm. The XRD analyses confirmed that the as-prepared CFA was amorphous nanoparticles. Furthermore, the amorphous CFA nanoparticles exhibited significantly enhanced dissolution property when compared to the commercial spray-dried product. The results demonstrated that the controlled nanoprecipitation method is a direct and feasible technology which could be utilized for preparation of the poorly water-soluble pharmaceutical nanoparticles.
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Banco de datos:
MEDLINE
Asunto principal:
Cefuroxima
/
Nanopartículas
Idioma:
En
Revista:
Int J Pharm
Año:
2006
Tipo del documento:
Article