Tandem intramolecular Michael-aldol reaction as a tool for the construction of the C-ring of hexacyclinic acid.
Org Lett
; 8(16): 3485-8, 2006 Aug 03.
Article
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| MEDLINE
| ID: mdl-16869641
ABSTRACT
[reaction see text] The tandem intramolecular Michael-aldol reaction was studied as a tool for the construction of the C-ring of hexacyclinic acid. By changing the reaction conditions it was possible to selectively obtain either the kinetic or the thermodynamic product. Retro-aldol reaction and subsequent epimerization provides four individual cyclopentane derivatives that can be incorporated as building blocks in natural product syntheses.
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Banco de datos:
MEDLINE
Asunto principal:
Macrólidos
/
Compuestos Heterocíclicos de 4 o más Anillos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Alemania