Hepatitis C virus (HCV) NS5B nonnucleoside inhibitors specifically block single-stranded viral RNA synthesis catalyzed by HCV replication complexes in vitro.
Antimicrob Agents Chemother
; 51(1): 338-42, 2007 Jan.
Article
en En
| MEDLINE
| ID: mdl-17088480
ABSTRACT
Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant to a nonnucleoside inhibitor lost their susceptibilities to the inhibitor.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ARN Viral
/
Proteínas no Estructurales Virales
/
Hepacivirus
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos