Effects of benidipine in a rat model for experimental angina.
Yakugaku Zasshi
; 126(12): 1377-81, 2006 Dec.
Article
en En
| MEDLINE
| ID: mdl-17139163
ABSTRACT
To compare the antianginal effects of 1,4-dihydropyridine-type calcium-channel blockers, we evaluated the effects of benidipine, amlodipine, nifedipine, and efonidipine on vasopressin-induced myocardial ischemia in rats, an experimental model of angina. Intravenous administration of benidipine (3 microg/kg), amlodipine (1000 microg/kg), and nifedipine (100 microg/kg) suppressed the vasopressin-induced S-wave depression, an index of myocardial ischemia. Efonidipine (100 microg/kg, i.v.) tended to inhibit the S-wave depression. At the antianginal dose of each drug, amlodipine, nifedipine, and efonidipine decreased blood pressure significantly, whereas benidipine had little effect on blood pressure at a dose of 3 microg/kg. These results indicate that benidipine, unlike the other 1,4-dihydropyridine-type calcium-channel blockers examined in this study, inhibits vasopressin-induced coronary vasospasm with fewer undesirable effects such as hypotension in rats, suggesting that benidipine may be useful in the treatment of angina pectoris.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Dihidropiridinas
/
Bloqueadores de los Canales de Calcio
/
Angina de Pecho
Límite:
Animals
Idioma:
En
Revista:
Yakugaku Zasshi
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón