Haplotype specific homology scanning algorithm to predict T-cell epitopes from protein sequences.
J Mol Recognit
; 4(1): 17-25, 1991 Feb.
Article
en En
| MEDLINE
| ID: mdl-1718340
ABSTRACT
We present a homology scanning microcomputer program to predict functional T-cell epitopes within proteins. By taking into account particular human or mouse restriction elements the predictions are made haplotype-specific. The generality of this approach is confirmed by (i) identification of well-characterized immunogenic T-cell determinants in lysozyme (ii) search for potential T epitopes on unanalysed proteins like the human beta 2-adrenoreceptor (iii) modification of non-immunogenic peptide sequences in order to generate T-cell determinants.
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Banco de datos:
MEDLINE
Asunto principal:
Algoritmos
/
Linfocitos T
/
Epítopos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Mol Recognit
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
1991
Tipo del documento:
Article
País de afiliación:
Francia