Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease.
Neurology
; 68(14): 1141-3, 2007 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-17215492
ABSTRACT
We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Serina
/
Proteínas Serina-Treonina Quinasas
/
Penetrancia
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Asesoramiento Genético
/
Glicina
Tipo de estudio:
Evaluation_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia