[Post-transfusion acute lung injury (Trali) after plasma infusion in a patient having a constitutional thrombotic microangiopathy]. / Syndrome d'oedème pulmonaire lésionnel aigu post-transfusionnel (Trali) après perfusion de plasma frais congelé au cours d'une microangiopathie thrombotique congénitale.
Rev Med Interne
; 28(7): 498-500, 2007 Jul.
Article
en Fr
| MEDLINE
| ID: mdl-17397970
ABSTRACT
INTRODUCTION:
Transfusion-related acute lung injury is a post-transfusion interstitial lung injury. CASE REPORT We reported a post-transfusion acute lung injury in a 23-years old woman having a chronic thrombotic microangiopathy related to an ADAMTS 13 constitutional deficiency receiving monthly plasma infusion for six years. The temporal relationship between the lung injury and the infusion of fresh frozen plasma led to the diagnosis of transfusion-related acute lung injury. The finding in the donor of the transfused plasma of an anti-HLA class II antibody recognizing HLA-DR52 present on leucocytes of the recipient suggests a causal relationship between this antigen-antibody conflict and the triggering of the TRALI. This chronic pathologic state requiring monthly plasma transfusions for thrombotic accident prevention raises the question of the selection of plasma obtained from non-immunized donors.CONCLUSION:
The occurrence of a post transfusion pulmonary edema without cardio-vascular overload, must lead to consider a TRALI especially in predisposing clinical situations. In the case reported the role of constitutional ADAMTS 13 deficiency in genesis of TRALI is considered.
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Banco de datos:
MEDLINE
Asunto principal:
Plasma
/
Síndrome de Dificultad Respiratoria
/
Trombosis
/
Transfusión de Componentes Sanguíneos
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
Fr
Revista:
Rev Med Interne
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia