5(Z)-benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators.

Ardecky, Robert J; Hudson, Andrew R; Phillips, Dean P; Tyhonas, John S; Deckhut, Charlotte; Lau, Thomas L; Li, Yongkai; Martinborough, Esther A; Roach, Steven L; Higuchi, Robert I; Lopez, Francisco J; Marschke, Keith B; Miner, Jeffrey N; Karanewsky, Donald S; Negro-Vilar, Andrés; Zhi, Lin

Ardecky, Robert J; Hudson, Andrew R; Phillips, Dean P; Tyhonas, John S; Deckhut, Charlotte; Lau, Thomas L; Li, Yongkai; Martinborough, Esther A; Roach, Steven L; Higuchi, Robert I; Lopez, Francisco J; Marschke, Keith B; Miner, Jeffrey N; Karanewsky, Donald S; Negro-Vilar, Andrés; Zhi, Lin.

Afiliación

Ardecky RJ; Discovery Research, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, CA 92121, USA.

Bioorg Med Chem Lett ; 17(15): 4158-62, 2007 Aug 01.

Article en En | MEDLINE | ID: mdl-17553679

ABSTRACT

ABSTRACT

A series of 5-benzylidene-1,2-dihydro-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes was synthesized and profiled for their ability to act as selective glucocorticoid receptor modulators (SGRMs). The synthesis and structure-activity relationships for this series of compounds are presented.

Asunto(s)

Crisenos/farmacología; Receptores de Glucocorticoides/efectos de los fármacos; Crisenos/síntesis química; Crisenos/química; Relación Estructura-Actividad

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Banco de datos: MEDLINE Asunto principal: Receptores de Glucocorticoides / Crisenos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos

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