[Preventive effect of shenfu injection on hepatic ischemia-reperfusion injury in rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
; 26 Suppl: 61-3, 2006 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-17569350
ABSTRACT
OBJECTIVE:
To investigate the protective effects of Shenfu Injection (SI) on hepatic ischemia-reperfusion injury in rats.METHODS:
Partial liver ischemia-reperfusion model under room temperature was established in 60 rats, which were divided into the control group and the treated group randomly and each group was again classified into 3 subgroups with 30 min, 60 min and 90 min hepatic ischemia time rspectively. Rats in the treated group were injected with SI 10 ml/kg every day, while the control group treated with normal saline. Survival rate after 1 week was observed, the serum levels of aspartate aminotransferase (AST), malondialde hyde (MDA), surperoxide dismutase (SOD), tumor nicrosis factor alpha (TNF-a) and endothelin (ET) were detected, and hepatic biopsy was performed with light and electronic microscope.RESULTS:
The survival rate in the treated subgroup with 90 min' ischemia after 1 week was 90%, higher than that in the control subgroup significantly (P <0. 05), which was 60% ; and serum levels of AST, MDA, TNF-alpha and ET were lower and SOD was higher significantly (all P <0.05), as well as the degenerative and necrotic degree of hepatocyte and sinusoidal endothelial cells was lighter in the 3 treated subgroups, compared with the control group.CONCLUSION:
Shenfu injection can eliminate oxygen free radical during hepatic ishemia-reperfusion so as to has a protective effect and attenuate hepatic ischemia reperfusion injury.
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Banco de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Daño por Reperfusión
/
Sustancias Protectoras
/
Hepatopatías
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Xi Yi Jie He Za Zhi
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2006
Tipo del documento:
Article