Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity.
Aging Cell
; 6(4): 547-56, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17578513
ABSTRACT
Age-associated and degenerative loss of functional integrity in soft tissues develops from effects of cumulative and subtle changes in their extracellular matrix (ECM). The highly ordered tendon ECM provides the tissue with its tensile strength during loading. As age and exercise collide in the high incidence of tendinopathies, we hypothesized that aged tendons fail due to cumulative damage resulting from a combination of diminished matrix repair and fragmentation of ECM proteins induced by prolonged cyclical loading, and that this is an active cell-mediated process. We developed an equine tendon explant model to examine the effect of age on the influence of prolonged cyclical loading at physiologically relevant strain rates (5% strain, 1 Hz for 24 h) on tissue mechanical properties, loss of ECM protein and matrix metalloproteinase (MMP) expression. We show significantly diminished mechanical strength of cyclically loaded tissue compared to controls (39.7 +/- 12%, P
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Banco de datos:
MEDLINE
Asunto principal:
Tendones
/
Envejecimiento
/
Metaloproteinasas de la Matriz
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Aging Cell
Año:
2007
Tipo del documento:
Article
País de afiliación:
Reino Unido