Escape mutations in HIV infection and its impact on CD8+ T cell responses.
Curr Mol Med
; 7(5): 446-58, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17691959
ABSTRACT
Cellular immune responses play an important role in the control of HIV replication. Although clear evidence exists on its influence during acute HIV infection, its role during the chronic phase of the disease remains controversial. This review describes the cellular immune responses elicited against HIV mediated by CD8(+) T lymphocytes, and the mechanisms by which these cells are inefficient to completely control HIV replication and halt disease progression. The role of escape mutations as one of the most relevant mechanisms HIV has developed to evade host cellular immune responses is highlighted.
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Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Linfocitos T CD8-positivos
/
Inmunidad Celular
/
Mutación
Límite:
Humans
Idioma:
En
Revista:
Curr Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2007
Tipo del documento:
Article
País de afiliación:
España