Immunomodulation against leukemias and lymphomas: a realistic future treatment?
Crit Rev Oncol Hematol
; 65(2): 101-8, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-17719232
ABSTRACT
Immunotherapy offers the potential for cure of malignancy without the side effects too commonly seen with conventional chemotherapy. The efficacy of allogenic transplantation and monoclonal antibodies in hematological malignancies illustrate this principle and are now part of routine care. Newer cell based and molecular approaches aimed at stimulating cytotoxic activity against host derived tumor associated antigens are able to 'boost' anti-tumor immunity as judged by immunological assays in vitro. Although clinically meaningful responses were originally less evident, more promising results are now being reported. Our growing understanding of tumor immunology provide rationales for further improvements in the field.
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Banco de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
/
Linfocitos T Citotóxicos
/
Leucemia
/
Vacunas contra el Cáncer
/
Inmunoterapia
/
Linfoma
Límite:
Humans
Idioma:
En
Revista:
Crit Rev Oncol Hematol
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
2008
Tipo del documento:
Article
País de afiliación:
Reino Unido