Biological investigation of 131I-labeled new water soluble Ru(II) polypyridyl complex.
Appl Radiat Isot
; 66(2): 115-21, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-17913501
ABSTRACT
New [Ru(L1)(dcbpy)(NCS)2] complex was synthesized in a one-pot reaction starting from [RuCl2(p-cymene)]2, where the ligands (dcbpy=4,4'-dicarboxy-2,2'-bipyridine, L1=dipyrido[3,2-a2',3'-c]phenazine-11-ylcarbonyl)-sodium) are introduced sequentially. The resulting complex was characterized by IR, NMR, and elemental analysis. The complex was labeled with I-131. Biodistribution study of the complex was carried out using 131I-labeled [Ru(L1)(dcbpy)(NCS)2] complex. The biodistribution study performed with albino Wistar male rats has shown that the complex has high uptake in the lung, small intestine, fat, and spleen.
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Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
Rutenio
/
Radiofármacos
/
Radioisótopos de Yodo
Límite:
Animals
Idioma:
En
Revista:
Appl Radiat Isot
Asunto de la revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Año:
2008
Tipo del documento:
Article
País de afiliación:
Turquía