Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.
Bioorg Med Chem Lett
; 17(23): 6525-8, 2007 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-17936624
ABSTRACT
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.
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Banco de datos:
MEDLINE
Asunto principal:
Receptores de Glutamato Metabotrópico
/
Naftiridinas
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos