Pre-mRNA splicing aberrations and cancer.
Front Biosci
; 13: 1090-105, 2008 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-17981615
ABSTRACT
Splicing requires the accurate recognition of exonic sequences from the surrounding thousands of nucleotides of intronic sequence and is achieved by the coordinate interplay of splicing regulatory elements in genes and the trans-acting RNA and protein molecules to which they bind. Infidelity in this process can have dramatic consequences for protein production, with an errors resulting in mRNA instability or the production of aberrant protein products. It is therefore not surprising that disruptions of splicing processes have been associated with a wide range of diseases, including cancer. This review looks at some of the mechanisms that regulate splicing and how disruption of such mechanisms can contribute to cancer susceptibility and progression.
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Banco de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
Regulación Neoplásica de la Expresión Génica
/
Empalme del ARN
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Regulación de la Expresión Génica
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Mutación
Límite:
Humans
Idioma:
En
Revista:
Front Biosci
Asunto de la revista:
BIOLOGIA
Año:
2008
Tipo del documento:
Article